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An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cardiovascular & heart health effects of cocoa flavanols The COSMOS trial Cognitive & brain health effects of cocoa flavanols The COSMOS-Web trial Uncover the benefits of flavanols Analytical methods of cocoa flavanol research Research publications
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Research publications

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Cardiovascular

Dose-related effects of flavanol-rich cocoa on blood pressure
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Chemistry

Enantioselective syntheses of sulfur analogues of flavan-3-Ols
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Chemistry

Synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin
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Cardiovascular

Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
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Cardiovascular

Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise
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Biological Effects

Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity
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Biological Effects

Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding
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Analytical Methods

Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples
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Microbiome

Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro
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Biological Effects

Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines
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Chemistry

TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells
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Cardiovascular

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo
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Biological Effects

Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects
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Biological Effects

Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
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Biological Effects

Selective cytotoxicity of synthesized procyanidin 3-O-galloylepicatechin-4b, 8-3-O-galloylcatechin to human cancer cells
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