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Published research

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Biological Effects

Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding.
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Biochemical Pharmacology logo View Abstract
Analytical Methods

Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples.
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Journal of Chromatography A logo View Abstract
Microbiome

Cocoa flavanols and procyanidins can modulate the lipopolysaccharide activation of polymorphonuclear cells in vitro.
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Journal of Medicinal Food logo View Abstract
Biological Effects

Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines.
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The Journal of Nutritional Biochemistry logo View Abstract
Chemistry

TNFalpha-induced NF-kappaB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells.
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Archives of Biochemistry and Biophysics logo View Abstract
Cardiovascular

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo.
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Archives of Biochemistry and Biophysics logo View Abstract
Biological Effects

Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects.
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International Journal of Obesity logo View Abstract
Biological Effects

Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial.
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Journal of the American College of Cardiology logo View Abstract
Biological Effects

Selective cytotoxicity of synthesized procyanidin 3-O-galloylepicatechin-4b, 8-3-O-galloylcatechin to human cancer cells.
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Cell Cycle logo View Abstract
Microbiome

Flavanol monomer-induced changes to the human faecal microflora.
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British Journal of Nutrition logo View Abstract
Biological Effects

Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations.
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Biochemical Pharmacology logo View Abstract
Biological Effects

Daily consumption of a dark chocolate containing flavanols and added sterol esters affects cardiovascular risk factors in a normotensive population with elevated cholesterol.
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The Journal of Nutrition logo View Abstract
Biological Effects

Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans.
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Reviews

Effects of cocoa flavanols on risk factors for cardiovascular disease.
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Analytical Methods

Cocoa flavanols - measurement, bioavailability and bioactivity.
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