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An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cardiovascular & heart health effects of cocoa flavanols The COSMOS trial Cognitive & brain health effects of cocoa flavanols The COSMOS-Web trial Uncover the benefits of flavanols Analytical methods of cocoa flavanol research Research publications
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Research publications

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Chemistry

Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates
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Analytical Methods

Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification
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Absorption & Metabolism

Influence of sugar type on the bioavailability of cocoa flavanols
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Biological Effects

Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study
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Chemistry

A versatile approach to the regioselective synthesis of diverse (−)-epicatechin-β-D-glucuronides
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Analytical Methods

Method for the determination of catechin and epicatechin enantiomers in cocoa-based ingredients and products by high-performance liquid chromatography: single-laboratory validation
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Cardiovascular

Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans
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Analytical Methods

Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards
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Biological Effects

Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts
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Analytical Methods

Physicochemical properties of acidified skim milk gels containing cocoa flavanols
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Chemistry

The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo
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Microbiome

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study
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Reviews

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs
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Brain/Cognitive Health

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway
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Brain/Cognitive Health

Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort
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