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An introduction to cocoa flavanols Cocoa flavanols and chocolate
Cardiovascular & heart health effects of cocoa flavanols The COSMOS trial Cognitive & brain health effects of cocoa flavanols The COSMOS-Web trial Uncover the benefits of flavanols Analytical methods of cocoa flavanol research Research publications
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Research publications

Find our latest research on cocoa flavanols, in collaboration with a global network of scientific partners

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Cardiovascular

Cocoa flavanols alleviate early diastolic dysfunction by decreasing left atrial volume in a randomized double blinded trial in healthy older individuals
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Cardiovascular

Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
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Cardiovascular

Cocoa flavanols have potential blood pressure (BP)-lowering effects in shorter-term, smaller-scale randomized clinical trials, but their effect on incident hypertension has not been examined in a large-scale and long-term randomized clinical trial
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Analytical Methods

Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers
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Analytical Methods

Definition of system suitability and proficiency testing acceptance criteria for the standardization of quality control methodologies of botanical bioactives: A case study for the development of AOAC Official Method of Analysis 2020.05 flavanols and procyanidins
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Absorption & Metabolism

Impact of polyphenol oxidase on the bioavailability of flavan-3-ols in fruit smoothies: a controlled, single blinded, cross-over study
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Analytical Methods

5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone Is a Substrate for Human Paraoxonase: A Novel Pathway in Flavan-3-ol Metabolism
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Brain/Cognitive Health

Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption
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Biological Effects

Flavan-3-ol-methylxanthine interactions: Modulation of flavan-3-ol bioavailability in volunteers with a functional colon and an ileostomy
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Other Biological Effects

Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial
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Analytical Methods

Determination of Cocoa Flavanols and Procyanidins (by Degree of Polymerization DP1-7) in Cocoa-Based Products by Hydrophilic Interaction Chromatography Coupled with Fluorescence Detection, Collaborative Study
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Cardiovascular

Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
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Analytical Methods

Evolution of cocoa flavanol analytics: impact on reporting and cross-study comparison
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Brain/Cognitive Health

Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
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Cardiovascular

Biomarker-estimated flavan-3-ol intake is associated with lower blood pressure in cross-sectional analysis in EPIC Norfolk
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